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KMID : 1094720200250010016
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Biotechnology and Bioprocess Engineering
2020 Volume.25 No. 1 p.16 ~ p.21
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Anti-inflammatory Effects of Sargachromanol I, Sargachromanol G, and Saringosterol from Hexane Fraction of Myagropsis myagroides
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Kim Koth-Bong-Woo-Ri
Jeong So-Mi
Jeong Da-Hyun
Kim Min-Ji
Ahn Dong-Hyun
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Abstract
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The anti-inflammatory activity of benzopyran derivatives extracted from the Myagropsis myagroides against lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophage cell line was examined. The three constituents of M. myagroides extracts were identified as the sargachromanol G, sargachromanol I, and saringosterol by 1H and 13C NMR. Sargachromanol G, sargachromanol I, and saringosterol at concentrations of 50 μg/mL showed inhibitory effects on LPS induced interleukin-6 production (by 84%, 90%, and 96%, respectively) and tumor necrosis factor (by 74%, 82%, and 98%, respectively). These results confirm the potential anti-inflammatory effects of sarga-chromanol G, sargachromanol I, and saringosterol.
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KEYWORD
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anti-inflammatory effect, Myagropsis myagroides, sargachromanol G, sargachromanol I, saringosterol
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